Effects of endotoxin on myocardial hemodynamics, performance, and metabolism during beta adrenergic blockade.
نویسندگان
چکیده
Office of Naval Research 11 ARSTRACT The question of the precise role of the heart in shock has been laroely unresolved. Previous separate reports have shown that both excitatory and depressant actions on the myocardium after endotoxin are observed. The purpose of the present study was to assay the possibility of a direct myocardial toxic aqtion of endotoxin or a circulatino mvocardial depressant factor released in the blood of endotoxin shocked animals. This was accomplished by utilization of beta adrenergic blockade (propranolol) under the experimental conditions of constant cardiac output and aortic pressure in an isolated canine heart preparation exchanqinc blood with an intact support animal shocked by endotoxin.
منابع مشابه
Effects of three beta adrenergic receptor agonists on growth performance, blood biochemical parameters, fatty acids composition and carnitine palmitoyltransferase I gene expression of rainbow trout Oncorhynchus mykiss
Different beta 1 and 2 adrenergic receptor agonists may be various biological and physiological effects on fish species. An experiment was designed to study the effects of feeding ractopamine, terbutaline and metaproterenol; as beta1, beta2 and less selective beta 2 adrenergic receptor agonists, respectively; on body weight gain, feed conversion ratio, concentration of biochemical parameters in...
متن کاملEffects of three beta adrenergic receptor agonists on growth performance, blood biochemical parameters, fatty acids composition and carnitine palmitoyltransferase I gene expression of rainbow trout, Oncorhynchus mykiss
Different beta 1 and 2 adrenergic receptors agonists might have various biological and physiological effects on fish species. An experiment was designed to study the effects of feeding ractopamine, terbutaline and metaproterenol; as beta1, beta2 and less selective beta2 adrenergic receptor agonists, respectively; on body weight gain, feed conversion rate, concentration of biochemical parameters...
متن کاملCholinergic modulation of the coronary vasoconstriction induced by cocaine in conscious dogs.
BACKGROUND The effects of cocaine on the coronary circulation were examined in conscious dogs chronically instrumented to measure arterial and left ventricular pressures, coronary blood flow, and arterial and coronary sinus oxygen content. METHODS AND RESULTS With heart rate held constant, the peak effects of cocaine (1 mg/kg i.v.) occurred within 2 minutes, when mean arterial pressure increa...
متن کاملEffects of Beta-Adrenergic Agents on Hypokalemia
288 Communications to the Editor food should interfere with nitrate effects.’ Recent hemodynamic studies in coronary patients indicate increased cardiac and stroke index without changes in mean arterial or pulmonary wedge pressures, which is consistent with the effect of food on STI in our Previous studies of normal conscious dogs were also in agreement, indicating an enhanced inotropic state d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
دوره 137 4 شماره
صفحات -
تاریخ انتشار 1971